Title: SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF AMPHIPHILIC COPOLYMER DERIVATIVES
Page Range: p.611-618
Author(s): Yongxiao Bai; Yaobin Liu; Yanfeng Li; Caiping Chang; Qi Zhang
File size: 397K
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Journal: Polymers and Polymer Composites
Issue Year: ppc
Volume: 19
Issue No: No.7
Abstract
A series of antimicrobial amphiphilic quaternised copolymers are synthesised through glycidyl methacrylate and styrene after poly(glycidyl methacrylate-co-styrene) modified by introduction of chloroethylic groups using chloroacetyl chloride. The antimicrobial activity of the obtained copolymers was evaluated against the gram-negative bacteria Escherichia coli, the gram-positive bacteria Bacillus subtilus, Staphyloccocus aureus Rosenbach and the fungus Monilia albican by the cut-plug method and Luria-Bertani broth suspended method. The research showed that the copolymer with the molar ratio of monomers 30:70 was the most effective against the microorganisms. The minimum inhibitory concentration (MIC) values of the polymer with against Staphyloccocus aureus Rosenbach and Monilia albican were found to be 31.3 and 32.1 (mu) g/mL, respectively, and these copolymers did not have any haemolytic action for mammalian erythrocytes. 36 Refs.
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