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Polymers and Polymer Composites

POLY(2-HYDROXY ETHYL METHACRYLATE-CO-ACRYLIC ACID) AS NOVEL BIODEGRADABLE MACROPOROUS HYDROGEL

August 1, 2005 By: Mohapatra R; Swain A K; Mohapatra R; Rana P K; Sahoo P K Research article

Title: POLY(2-HYDROXY ETHYL METHACRYLATE-CO-ACRYLIC ACID) AS NOVEL BIODEGRADABLE MACROPOROUS HYDROGEL
Page Range: p.807-814
Author(s): Mohapatra R; Swain A K; Mohapatra R; Rana P K; Sahoo P K
File size: 202K
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Journal: Polymers and Polymer Composites
Issue Year: ppc
Volume: 13
Issue No: No. 8

Abstract
The main purpose of this work was to develop a new copolymer hydrogel, poly(2-hydroxy ethyl methacrylate-co-acrylic acid(P(HEMA-co-AA) with a crosslinker, MBA, because of its future prospects in drug delivery. The structure of the copolymer was characterised by FTIR, H-NMR and SEM, and its thermal stability was investigated by thermogravimetric analysis. Its hydrogel character was observed by studying the swelling of the copolymers by measuring weight gain and loss. The biodegradability of the copolymers was studied by introducing microbes into the culture media along with the prepared sample, and it was verified by examining the surface morphology by SEM. The rate of biodegradation was monitored by the carbon dioxide release method. Results indicated that the copolymer as suitable for implementation in various drug delivery systems and in the manufacture of medical devices for diagnostic purposes, because of its hydrogel character and inter-communicating macropores, along with its high thermal stability. 36 refs.

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