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Polymers and Polymer Composites

Medicated multiple-component polymeric nanocomposites fabricated using electrospraying

January 1, 2017 By: Yong-Hui Wu; Deng-Guang Yu; Jiao-Jiao Li; Qing Wang; Hai-Peng Li; Xiao-Yan Li Research article

Title: Medicated multiple-component polymeric nanocomposites fabricated using electrospraying
Page Range: p.57-62
Author(s): Yong-Hui Wu; Deng-Guang Yu; Jiao-Jiao Li; Qing Wang; Hai-Peng Li; Xiao-Yan Li
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Journal: Polymers and Polymer Composites
Issue Year: ppc
Volume: 25
Issue No: No.1

Abstract
Drug-loaded hydrophilic polymeric composite (HPC) is one of the most promising biomaterials for resolving the long-standing challenge of the development of oral solid formulations for insoluble drugs. With polyvinylpyrrolidone K10 (PVP) as polymeric carrier and sodium dodecyl sulphonate (SDS) as a surface active agent, a new type of HPC was fabricated for enhancing the dissolution of quercetin using an electrospraying process. A solvent mixture consisting of acetic acid, acetone and ethanol were exploited to prepare the codissolving solution of quercetin, PVP, and SDS for creating HPC. Both the sprayed nanoparticles and casting film fabricated using a thermal solvent evaporation process were amorphous composites, as demonstrated by the XRD results. ATR-FTIR spectra verified that the drug and the pharmaceutical carriers had good compatibility. In vitro dissolution experiments showed that the sprayed HPC could provide an over ten-fold faster dissolution rate than the casting film. Electrospraying is a facile method for developing new kinds of HPCs for insoluble drugs. 17 Refs.

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