Title: CHARACTERIZATION OF BIOCOMPATIBLE SCAFFOLDS BASED ON GELATIN AND HYALURONIC ACID FOR FIBROBLASTS CULTURE
Page Range: p.791-796
Author(s): Zhihua Zhou; Zhongmin Yang; Tianlong Huang; Lihua Liu; Qingquan Liu; Wennan Zeng; Dafu Cao; Songjiang Ma
File size: 389K
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Journal: Polymers and Polymer Composites
Issue Year: ppc
Volume: 20
Issue No: No.9
Abstract
Gelatin/hyaluronic acid (Gel/HA) scaffolds were prepared by using the freeze-drying method after crosslinking with 1-ethyl-(3-3-dimethylaminopropyl) carbodiimide (EDC). The porous structure was characterized by scanning electron microscopy (SEM), and the wettability of Gel/HA film was also studied by measuring their contact angle. The biological behaviour of the scaffolds was analysed by studying the cell behaviour using a fibroblast cell line and standard biological MTT test. The results showed that the scaffold had an inter-connected pore structure with a sufficient pore size for use as a support for the growth of fibroblasts. The contact angle decreased with increasing HA content, whereas the cell attachment and proliferation improved with decreasing HA content. Confocal laser scanning microscopy (CLSM) demonstrated a normal cell distribution and proliferation on the porous Gel/HA scaffolds. 20 Refs.
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