Title: AN AROMATIC MACROMOLECULE AS A NANO DRUG CARRIER: POLYETHER DENDRIMER / POLY(2-HYDROXYETHYL METHACRYLATE)
Page Range: p.429-434
Author(s): Reza Saboktakin M; Tabatabaie R M; Maharramov A; Ramazanov M A
File size: 295K
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Journal: Polymers and Polymer Composites
Issue Year: ppc
Volume: 18
Issue No: No.8
Abstract
Highly branched, functionalised polymers have the potential to act as efficient drug carrier systems. The aromatic polyether dendrimers are spherical, highly ordered, multibranched, nanometre-sized macromolecules having positively charged ether groups on the surface under physiological conditions. In this study, we have synthesised a kind of dendrimer/poly(2-hydroxy ethyl methacrylate) nanocomposite/5-aminosalicylic acid (5-ASA) for oral drug delivery. The aromatic polyether dendrimer (generation 2, hyperbranched polyether with -CH2OH functionality, 3,5-Dihydroxybenzoic acid core) was prepared from generation 2, hyperbranched polyether dendrimer with -COOCH3 form in excellent yield. FT-IR, 1H-NMR and DSC studies suggest that the monomer predominantly forms a complex with polyether dendrimers because of the interaction between the -CH2OH end groups of dendrimer and the -OH group of 2-hydroxyethyl methacrylate monomer. 15 Refs.
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