# EVALUATION OF BIOLOGICAL PROPERTIES IN-VIVO OF POLY(L-LACTIDE-COGLYCOLIDE) COMPOSITES CONTAINING BIOACTIVE GLASS

> Title: EVALUATION OF BIOLOGICAL PROPERTIES IN-VIVO OF POLY(L-LACTIDE-COGLYCOLIDE) COMPOSITES CONTAINING BIOACTIVE GLASS Page Range: p.79-84 Author(s): Zhihua Zhou; Lihua Liu; Qingquan Liu; Tianlong Huang; Wennan Zeng; Qingfeng Yi; Zhongmin Yang; Dafu Cao File size: Download the pdf (subscribers only) Buy the pdf...

Canonical URL: https://polymerjournals.com/evaluation-of-biological-properties-in-vivo-of-polyl-lactide-coglycolide-composites-containing-bioactive-glass/
Published: 2013-02-01T00:00:00+00:00
Categories: Polymers and Polymer Composites

**Title: EVALUATION OF BIOLOGICAL PROPERTIES IN-VIVO OF POLY(L-LACTIDE-COGLYCOLIDE) COMPOSITES CONTAINING BIOACTIVE GLASS**
 Page Range: p.79-84
 Author(s): Zhihua Zhou; Lihua Liu; Qingquan Liu; Tianlong Huang; Wennan Zeng; Qingfeng Yi; Zhongmin Yang; Dafu Cao
 File size:
 ![](http://dload.gif) [Download the pdf](http://journals.asp?Page=111&JournalDownload=ON&JournalType=ppc&JournalIssue=ppc21-2&JournalID=101828&JIP=) (subscribers only)
 ![](http://handbuy.gif) Buy the pdf (non-subscribers)
 Journal: Polymers and Polymer Composites
 Issue Year: ppc
 Volume: 21
 Issue No: No.2

**Abstract**
 To evaluate the biological safety of composite materials based on poly(L-lactide-co-glycolide) (PLGA) and bioactive glass (BG), which have a potential application in tissue engineering, the in-vivo biological properties were investigated by applying the micronucleus test, acute systemic toxicity test, haemolytic test and pyrogen measurement. The results indicated that the PLGA/BG composite showed no genetic toxicity; there was no toxicosis or death observed in the acute systemic toxicity test. The haemolytic test suggested that the PLGA/BG composite, with a haemolytic index of 0.281%, did not have an obvious haemolytic reaction. In addition, the PLGA/BG composite materials showed no pyrogen reaction. Therefore, PLGA/BG composite materials could be promising candidate biomedical materials for bone tissue engineering. 20 Refs.

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