# Evaluation of a smart polymer nanosphere for potential use in anticancer drug delivery

> Title: Evaluation of a smart polymer nanosphere for potential use in anticancer drug delivery Page Range: p.753-762 Author(s): Rubini Vimalarasa; Foot P J S; Gianpiero Calabrese File size: Download the pdf (subscribers only) Buy the pdf (non-subscribers) Journal: Polymers and Polymer Composites...

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Published: 2014-09-01T00:00:00+00:00
Categories: Polymers and Polymer Composites

**Title: Evaluation of a smart polymer nanosphere for potential use in anticancer drug delivery**
 Page Range: p.753-762
 Author(s): Rubini Vimalarasa; Foot P J S; Gianpiero Calabrese
 File size:
 ![](http://dload.gif) [Download the pdf](http://journals.asp?Page=111&JournalDownload=ON&JournalType=ppc&JournalIssue=ppc22-9&JournalID=102324&JIP=) (subscribers only)
 ![](http://handbuy.gif) Buy the pdf (non-subscribers)
 Journal: Polymers and Polymer Composites
 Issue Year: ppc
 Volume: 22
 Issue No: No.9

**Abstract**
 Polypyrrole-chitosan (ppy-chit) hollow nanospheres have been synthesised using a simple route wherein dispersion polymerisation of pyrrole was followed by treatment with aqueous ammonia, centrifugation and dialysis. Ppy-chit hollow nanospheres were characterised by techniques including transmission electron microscopy, atomic force microscopy, powder x-ray diffractometry and UV-visible spectrophotometry. The particle size and stability were assessed by using a Zetasizer. A model anticancer drug, Nile blue chloride, was loaded into the ppy-chit hollow nanospheres by adsorption, and the desorption profile showed that 88% of the dye was released at a typical physiological pH over a period of 5 hours. The combined molecular properties of chitosan and polypyrrole were beneficial to the drug delivery. 20 Refs.

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