# AN AROMATIC MACROMOLECULE AS A NANO DRUG CARRIER: POLYETHER DENDRIMER / POLY(2-HYDROXYETHYL METHACRYLATE)

> Title: AN AROMATIC MACROMOLECULE AS A NANO DRUG CARRIER: POLYETHER DENDRIMER / POLY(2-HYDROXYETHYL METHACRYLATE) Page Range: p.429-434 Author(s): Reza Saboktakin M; Tabatabaie R M; Maharramov A; Ramazanov M A File size: 295K Download the pdf (subscribers only) Buy the pdf (non-subscribers) Journal:...

Canonical URL: https://polymerjournals.com/an-aromatic-macromolecule-as-a-nano-drug-carrier-polyether-dendrimer-poly2-hydroxyethyl-methacrylate/
Published: 2010-08-01T00:00:00+00:00
Categories: Polymers and Polymer Composites

**Title: AN AROMATIC MACROMOLECULE AS A NANO DRUG CARRIER: POLYETHER DENDRIMER / POLY(2-HYDROXYETHYL METHACRYLATE)**
 Page Range: p.429-434
 Author(s): Reza Saboktakin M; Tabatabaie R M; Maharramov A; Ramazanov M A
 File size: 295K
 ![](http://dload.gif) [Download the pdf](http://journals.asp?Page=111&JournalDownload=ON&JournalType=ppc&JournalIssue=ppc18-8&JournalID=101233&JIP=) (subscribers only)
 ![](http://handbuy.gif) Buy the pdf (non-subscribers)
 Journal: Polymers and Polymer Composites
 Issue Year: ppc
 Volume: 18
 Issue No: No.8

**Abstract**
 Highly branched, functionalised polymers have the potential to act as efficient drug carrier systems. The aromatic polyether dendrimers are spherical, highly ordered, multibranched, nanometre-sized macromolecules having positively charged ether groups on the surface under physiological conditions. In this study, we have synthesised a kind of dendrimer/poly(2-hydroxy ethyl methacrylate) nanocomposite/5-aminosalicylic acid (5-ASA) for oral drug delivery. The aromatic polyether dendrimer (generation 2, hyperbranched polyether with -CH2OH functionality, 3,5-Dihydroxybenzoic acid core) was prepared from generation 2, hyperbranched polyether dendrimer with -COOCH3 form in excellent yield. FT-IR, 1H-NMR and DSC studies suggest that the monomer predominantly forms a complex with polyether dendrimers because of the interaction between the -CH2OH end groups of dendrimer and the -OH group of 2-hydroxyethyl methacrylate monomer. 15 Refs.

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